Crossing three membranes Channel formation by aerolysin
نویسندگان
چکیده
منابع مشابه
Interactions between aerolysin, erythrocytes, and erythrocyte membranes.
Aerolysin, a hemolytic and lethal exotoxin of Aeromonas hydrophila, was analyzed for amino acids. Assuming 8 histidine residues/mol, the purified toxic protein has, by summation, a molecular weight of 49,000, a value in agreement with earlier estimates by other methods. Erythrocytes from different animal species differ greatly in sensitivity to aerolysin's lytic action. There is some correlatio...
متن کاملA rivet model for channel formation by aerolysin-like pore-forming toxins.
The bacterial toxin aerolysin kills cells by forming heptameric channels, of unknown structure, in the plasma membrane. Using disulfide trapping and cysteine scanning mutagenesis coupled to thiol-specific labeling on lipid bilayers, we identify a loop that lines the channel. This loop has an alternating pattern of charged and uncharged residues, suggesting that the transmembrane region has a be...
متن کاملCrossing Membranes
space should have been devoted to describing the ex-age of cell biology. The book does not include sections periments that led to this information. For example, a on immunology/immunity, cancer, or development, section in Chapter 46 (box 46-1) contains a synopsis leaving these topics for more specialized texts, which I of key experiments in cell cycle research that I found personally find appro...
متن کاملMolecular aspects of channel formation and ion transport through membranes
A summary Is presented of theoretlcal studles almlng at a better understandlng of the coupling propertles of polypeptlde a-helical segments. and of their aggregation into bundles of various sizes capable of encloslng channels apt to transport Ions through biological membranes. The molecular aspects are stressed. INTRODUCTION Blologlcal membranes surround the cells and thelr varlous compartments...
متن کاملCase Report: Formation of Median Nerve by Three Roots
Atypical connections in the formation of the brachial plexus are prevalent and have been reported in different articles. The present report describes a case of variation of the median nerve observed in the Iranian male cadaver during routine trial dissection. There are three roots for median nerve. Median nerve is formed by joining two lateral and medial cords of brachial plexus. Third root ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 1992
ISSN: 0014-5793
DOI: 10.1016/0014-5793(92)80896-o